We thank Upton for his comments1 on our article.2We agree that the Joint Committee on Vaccination and Immunisation (JCVI) needs to operate in a transparent manner. We also agree that the JCVI needs a suitable level of administrative and financial support to carry out its work effectively. The National Institute for Health and Care Excellence (NICE) provides good examples of transparent working, partnerships with patients and the public, and publication of timely reports on its work and guidance for health professionals.3 NICE also ensures that its work on guidelines examines equality and diversity matters.The JCVI was working under difficult circumstances, aiming to produce guidance on covid-19 vaccination during a pandemic that was the biggest public health crisis to face the UK since the second world war. This guidance had to be produced while evidence on the risks and benefits of covid-19 vaccines was still emerging and often incomplete: for example,…

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