Obesity is a medical condition in which too
much body fat negatively impacts your health. It is healthy to have some body
fat. In fact, a healthy level of body fat is needed to survive. But too much
fat can be harmful to your body. Obesity is most often measured by body mass
index (BMI), a calculation of body weight compared with height. BMI isn’t the
only way to measure healthy weight. For most adults trying to shed pounds diet
and exercise mostly fail in the long term. Recently new evidence-based
guidelines were released by American Gastroenterological Association strongly
recommending that these patients with obesity use recently approved medications
coupled together with lifestyle changes.

The following medications, paired with healthy
eating and regular physical activity, are first-line medical options and result
in moderate weight loss as noted as a percentage of body weight (reported as
the difference compared to percent weight loss observed in the placebo group).

Semaglutide, weight loss percentage: 10.8%

Phentermine-topiramate ER, weight loss
percentage: 8.5%

Liraglutide, weight loss percentage: 4.8%

Naltrexone-Bupropion ER, weight loss percentage:

“These medications treat a biological disease,
not a lifestyle problem. Obesity is a disease that often does not respond to
lifestyle interventions alone in the long-term,” says author Eduardo
Grunvald.”Using medications as an option to assist with weight loss can improve
weight-related complications like joint pain, diabetes, fatty liver and


Grunvald, et al,AGA Clinical Guidelines
on Pharmacological Interventions for Adults with

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