Preneoplastic Lesions highly prevalent in first-degree relatives of gastric cancer patients

Worldwide, gastric cancer (GC) is the 5th cancer with the highest incidence and the 4th in mortality. To reduce it, one strategy is to diagnose preneoplastic lesions (PNL): atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia (DYS); to form risk groups on which to focus surveillance efforts as are first-degree relatives (FDR).

Preneoplastic Lesions are prevalent in first-degree
relatives of patients with gastric cancer Journal of Gastrointestinal Cancer
according to a recent study published in the Journal of Gastrointestinal Cancer.

Worldwide, gastric cancer (GC) is 5th cancer with the
highest incidence and the 4th in mortality. To reduce it, one strategy is to
diagnose preneoplastic lesions (PNL): atrophic gastritis (AG), intestinal
metaplasia (IM), and dysplasia (DYS); to form risk groups on which to focus
surveillance efforts as are first-degree relatives (FDR). The aim of this study
was to determine the prevalence of gastric PNL in FDR of patients with GC, and to
study the association with sex, age, and Helicobacter pylori (Hp) infection.

Cross-sectional study. One hundred and ten FDR, aged between
50 and 65 years, 54.5 female, obtained through convenience sampling, were
studied. Biodemographic data survey and upper gastrointestinal endoscopy with the histological study were applied according to Sidney protocol, and focal lesions
found. Diagnosis of these lesions and condition of mucosa was carried out by
applying OLGA and OLGIM systems. Descriptive statistics, estimation of
prevalence, odds ratio (OR), and 95% confidence intervals (95CI) were
calculated.

Results:

Median age of study group was 56.5 years.
Prevalence of PNL, AG, IM, and DYS were 86.4%, 82.7%, 54.5%, and 12.7%
respectively. Advanced stages of OLGA and OLGIM were verified
in 18.0% and 16.3% respectively. No association with sex, age, and Hp infection
were found respectively.

Thus, FDR of patients with GC have a high prevalence of PNL,
which makes them a risk group in which endoscopic surveillance should be
applied.

Reference:

Prevalence of Gastric Preneoplastic Lesions in First-Degree
Relatives of Patients with Gastric Cancer: a Cross-Sectional Study by Sergio
Sotelo et al. published in the Journal of Gastrointestinal Cancer

DOI: 10.1007/s12029-022-00827-x

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