Several cross-sectional studies worldwide
have reported a high prevalence (20– 64%) of hypogonadism among males with diabetes
mellitus. Association between hypogonadism and DM has recently been drawing
public health attention. Hypogonadism (low testosterone) has been classically
linked with sexual dysfunction. But recent data show that it is also linked
with insulin resistance (IR), obesity, metabolic syndrome (MS), incident DM,
dyslipidemia, cardiovascular disease, depression, and poor quality of life.

Despite all these, few studies on
hypogonadism in newly onset DM are done from the Eastern part of India. So, the
authors carried out a cross-sectional study to know the magnitude of the
problem and predictor of hypogonadism in this part of India as ethnicity and
lifestyle vary from region to region.

A total of 231 consecutive newly diagnosed
males with type 2 DM were enrolled. Patients were stratified into group A (hypogonadal)
and group B (eugonadal) based on TT level. Mean value of age, body mass index
(BMI), A1c, waist circumference (WC), TC, TG, LDL, high-density lipoprotein
(HDL), systolic blood pressure (SBP), diastolic blood pressure (DBP), uric acid
(UA), and glomerular filtration rate (eGFR) in group A and group B were compared.
It was found that the prevalence of hypogonadism was 38.53%.

Hence, it was concluded that the
prevalence of hypogonadism is high in newly diagnosed DM. BMI, central obesity
and triglyceride levels are significantly associated with low Testosterone. So
obese and hyper- triglyceride patients should be evaluated for Testosterone
levels at the time of diagnosis. These patients should be treated with drugs
that promote weight loss, reduce insulin resistance, and raise Testosterone
levels.

Reference:

Shailendra Kumar Singh, Rina
Singh , Santosh Kumar Singh, Pradeep Kumar Rai. Prevalence and Predictor of
Hypogonadism in Newly Onset Type 2 Diabetes Mellitus: A Cross-sectional Study.
JAPI 2022; Vol 70.

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