What you need to knowProton pump inhibitors (PPIs) are effective and widely used, but often for longer than needed, adding to medication burden and resource wasteDiscuss with patients reducing or stopping PPIs if they have been taken for longer than eight weeks unless there is a specific indication for long term usePPI deprescribing options include dose reduction, stopping, switching to “on demand” use, and using alternative antacid medication with non-drug approaches to avoid or manage heartburnA management plan for rebound heartburn after stopping a PPI is helpful, and may include returning to the original dose if symptoms are severeProton pump inhibitors (PPIs) are one of the most widely used classes of drugs globally, often taken for longer than needed and at high financial cost to society. Among adults living in the community, the point prevalence of PPI use is 7-8% in the UK and Denmark,12 while rates of use of…

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