Reducing sedentary time with increasing physical activity may cut CVD and premature deaths: JAMA

Reducing sedentary time along with increasing physical activity may be an important strategy for easing the global burden of premature deaths and CVD according to a recent study published in the JAMA Cardiology. 

High
amounts of sitting time are associated with increased risks of cardiovascular
disease (CVD) and mortality in high-income countries, but it is unknown whether
risks also increase in low- and middle-income countries.

A study was
conducted to investigate the association of sitting time with mortality and
major CVD in countries at different economic levels using data from the
Prospective Urban Rural Epidemiology study. This population-based cohort study
included participants aged 35 to 70 years recruited from January 1, 2003, and
followed up until August 31, 2021, in 21 high-income, middle-income, and
low-income countries with a median follow-up of 11.1 years.

Results:

Of
105 677 participants, 61 925 (58.6%) were women, and the mean (SD) age was
50.4 (9.6) years. During a median follow-up of 11.1 (IQR, 8.6-12.2) years, 6233
deaths and 5696 major cardiovascular events were documented. Compared
with the reference group (<4 hours per day of sitting), higher sitting time
(≥8 hours per day) was associated with an increased risk of the composite
outcome, all-cause mortality and major CVD When
stratified by country income levels, the association of sitting time with the
composite outcome was stronger in low-income and lower-middle–income countries compared
with high-income and upper-middle–income countries Compared
with those who reported sitting time less than 4 hours per day and high
physical activity level, participants who sat for 8 or more hours per day
experienced a 17% to 50% higher associated risk of the composite outcome across
physical activity levels; and the risk was attenuated along with increased
physical activity levels.

Thus, High
amounts of sitting time were associated with increased risk of all-cause
mortality and CVD in economically diverse settings, especially in low-income
and lower-middle–income countries. Reducing sedentary time along with
increasing physical activity might be an important strategy for easing the
global burden of premature deaths and CVD.

Reference:

Association
of Sitting Time With Mortality and Cardiovascular Events in High-Income,
Middle-Income, and Low-Income Countries by Sidong Li, et al. published in the JAMA
cardiology.

doi:10.1001/jamacardio.2022.1581

Keywords:

Association,
Sitting, Time, Mortality, Cardiovascular, Events, High-Income, Middle-Income,
and Low-Income Countries, Sidong Li, jama network, Scott A. Lear, Sumathy
Rangarajan, Bo Hu, Lu Yin, Shrikant I. Bangdiwala, Khalid F. Alhabib, Annika
Rosengren, Rajeev Gupta, Prem K. Mony, Andreas Wielgosz, Omar Rahman, M. Y.
Mazapuspavina, JAMA cardiology

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